pandas文档表示，它对xlsx文件使用openpyxl。快速浏览一下其中的代码ExcelWriter可以提示可能会发生以下情况：
import pandas
from openpyxl import load_workbook
book = load_workbook('Masterfile.xlsx')
writer = pandas.ExcelWriter('Masterfile.xlsx', engine='openpyxl')
writer.book = book
writer.sheets = dict((ws.title, ws) for ws in book.worksheets)
data_filtered.to_excel(writer, "Main", cols=['Diff1', 'Diff2'])
writer.save()
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