看来，附带的wxPython 2.7 DMG C扩展模块这里是仅32位。
$ cd /usr/local/lib/wxPython-unicode-2.8.11.0/lib/python2.7/site-packages/wx-2.8-mac-unicode/wx
$ file *.so
_animate.so: Mach-O universal binary with 2 architectures
_animate.so (for architecture ppc): Mach-O bundle ppc
_animate.so (for architecture i386): Mach-O bundle i386
_aui.so: Mach-O universal binary with 2 architectures
_aui.so (for architecture ppc): Mach-O bundle ppc
_aui.so (for architecture i386): Mach-O bundle i386
...
不幸的是，platform.architecture()它不能准确指示Python正在运行的OS X多种体系结构。例如，对于Python 2.7使用3-arch python.org安装程序，platform.architecture()即使在32位模式下运行，也始终报告64位。 ：
$ cd /Library/Frameworks/Python.framework/Versions/2.7
$ file python2.7
python2.7: Mach-O universal binary with 3 architectures
python2.7 (for architecture i386): Mach-O executable i386
python2.7 (for architecture ppc7400): Mach-O executable ppc
python2.7 (for architecture x86_64): Mach-O 64-bit executable x86_64
$ arch -x86_64 ./python2.7 -c 'import platform, sys; print "{0}, {1:x}".format(platform.architecture()[0], sys.maxint)'
64bit, 7fffffffffffffff
$ arch -i386 ./python2.7 -c 'import platform, sys; print "{0}, {1:x}".format(platform.architecture()[0], sys.maxint)'
64bit, 7fffffff
$ arch -ppc ./python2.7 -c 'import platform, sys; print "{0}, {1:x}".format(platform.architecture()[0], sys.maxint)'
64bit, 7fffffff
可靠的方法是检查sys.maxintPython 2或sys.maxsizePython 3。
您没有在问题中指出如何调用Python。是通过脚本文件中的shebang行吗？如果是这样，您可能没有运行您认为是的Python。另外，您不会指出已安装的Python 2.7。例如，当前有两个来自python.org的Python 2.7安装程序：一个安装程序同时支持32位和64位执行，另一个仅支持32位。请尝试以下操作：
$ file $(python2.7 -c 'import sys;print(sys.executable)')
/Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python: Mach-O universal binary with 3 architectures
/Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python (for architecture i386): Mach-O executable i386
/Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python (for architecture ppc7400): Mach-O executable ppc
/Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python (for architecture x86_64): Mach-O 64-bit executable x86_64
因此：如果您具有Python的多体系结构版本，则需要强制其以32位模式运行，以利用预编译的wxPython。
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