好吧，我不想成为回答我自己问题的人，但似乎没人知道。我留下后人的答案。
APPNAME = "MyApp"
import sys
from os import path, environ
if sys.platform == 'darwin':
from AppKit import NSSearchPathForDirectoriesInDomains
# http://developer.apple.com/DOCUMENTATION/Cocoa/Reference/Foundation/Miscellaneous/Foundation_Functions/Reference/reference.html#//apple_ref/c/func/NSSearchPathForDirectoriesInDomains
# NSApplicationSupportDirectory = 14
# NSUserDomainMask = 1
# True for expanding the tilde into a fully qualified path
appdata = path.join(NSSearchPathForDirectoriesInDomains(14, 1, True)[0], APPNAME)
elif sys.platform == 'win32':
appdata = path.join(environ['APPDATA'], APPNAME)
else:
appdata = path.expanduser(path.join("~", "." + APPNAME))
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